Integrating Indigenous Knowledge through Contextual Project-Based Learning: Student–Healer Collaboration and Phytochemical Investigation of Traditional Ethnomedicine in Lombok, Indonesia

Authors

  • Faizul Bayani Qamarul Huda Badaruddin Bagu University
  • Joni Rokhmat Mataram University
  • Aliefman Hakim Mataram University
  • AA Sukarso Mataram University

DOI:

https://doi.org/10.33394/j-ps.v13i3.17348

Keywords:

Ethnomedicine, Project-Based Learning (PjBL), Phytochemical Screening, Indigenous Knowledge, Pharmaceutical Education

Abstract

This study investigates the implementation of a contextual Project-Based Learning model (Ethnomed-PjBL) that connects pharmacy students with traditional healers (Belian) in Lombok, Indonesia, to explore and scientifically validate ethnomedicinal formulations. Conducted in three phases field immersion, in-situ qualitative testing, and laboratory-based phytochemical analysis the model facilitated reciprocal learning and empirical inquiry grounded in Indigenous healing knowledge. Laboratory screening confirmed the presence of key secondary metabolites across all formulations, including flavonoids, tannins, alkaloids, phenolics, and terpenoids. Among the seven formulations tested, those based on Ziziphus mauritiana (bidara) and Annona muricata (soursop) showed the highest chemical diversity and antioxidant activity, with IC₅₀ values of 61.2 µg/mL and 74.5 µg/mL, respectively. These results support the pharmacological potential of traditional remedies and align with healer-reported uses related to immune function and disease prevention. Students reported significant educational gains, including improved understanding of phytochemistry, enhanced laboratory competence, critical thinking, and greater intercultural and ethical awareness. The Ethnomed-PjBL model demonstrated the capacity to embed scientific inquiry within culturally responsive frameworks, reinforcing the relevance of Indigenous knowledge in contemporary pharmaceutical education. By promoting equitable academic–community partnerships, this model contributes to broader efforts to decolonize health education and advance pharmaceutical sovereignty. It offers a replicable framework for integrating traditional knowledge into vocational health curricula, balancing scientific rigor with cultural respect. The study underscores the importance of ethical collaboration in preserving traditional knowledge systems while cultivating future health professionals who are both scientifically competent and culturally attuned.

References

Addison, C., Jenkins, B., White, M., Odom, D., Fortenberry, M., Wilson, G., … & LaVigne, D. (2021). Twenty years of leading the way among cohort studies in community-driven outreach and engagement: jackson state university/jackson heart study. International Journal of Environmental Research and Public Health, 18(2), 696. https://doi.org/10.3390/ijerph18020696

Adesida, F., Oluyole, K., Agulanna, F., Oladokun, Y., Adelusi, A., Agboola, L., … & Mustopha, F. (2021). Kola as an indispensable article of trade in west africa. World Journal of Advanced Research and Reviews, 12(2), 324-331. https://doi.org/10.30574/wjarr.2021.12.2.0533

Afrianti, H., Viona, E., & Efriyadi, E. (2024). Literature study: school and community partnership model to improve the quality of educational environment. PIJED, 3(2), 357-366. https://doi.org/10.59175/pijed.v3i2.327

Al-musawi, M. (2017). Evaluation of lousicidal activity of ziziphus mauritiana alkaloids and eucaylptus camaldulensis terpenoids leaves extracts in chickens: an in vitro study. Al-Kufa University Journal for Biology, 9(2), 1-8. https://doi.org/10.36320/ajb/v9.i2.7598

Alum, E. (2025). Metabolomics-driven standardization of herbal medicine: advances, applications, and sustainability considerations. Natural Product Communications, 20(8). https://doi.org/10.1177/1934578x251367650

Aminullah, E. (2022). Dynamics of capability upgrading in indonesian herbal medicine firms. Sti Policy and Management Journal, 7(2). https://doi.org/10.14203/stipm.2022.348

Ana, A., Subekti, S., & Hamidah, S. (2015). The patisserie project based learning model to enhance vocational students’ generic green skills.. https://doi.org/10.2991/ictvet-14.2015.6

Apsari, Y., Mulyani, E., & Lisdawati, I. (2019). Students’ attitudes toward implementation of project based learning. Journal of Educational Experts (Jee), 2(2), 123. https://doi.org/10.30740/jee.v2i2p123-128

Askar, M., Thangjam, N., & Kumar, A. (2025). A review on pharmacological importance of polyherbal formulation. Research Journal of Pharmacy and Technology, 1925-1930. https://doi.org/10.52711/0974-360x.2025.00275

Azher, S., Mills, A., He, J., Hyjazie, T., Tokuno, J., Quaiattini, A., … & Harley, J. (2024). Findings favor haptics feedback in virtual simulation surgical education: an updated systematic and scoping review. Surgical Innovation, 31(3), 331-341. https://doi.org/10.1177/15533506241238263

Belbasis, L. and Panagiotou, O. (2022). Reproducibility of prediction models in health services research. BMC Research Notes, 15(1). https://doi.org/10.1186/s13104-022-06082-4

Bessette, N., Reade, M., McGregor, L., Berti, J., Naokwegijig, B., & Maar, M. (2023). Culturally safe practices in the co-creation of medical education curriculum with indigenous animators: outcomes from an indigenous learning circle. Journal of Medical Education and Curricular Development, 10. https://doi.org/10.1177/23821205231219430

Bromley, E., Eisenman, D., Magaña, A., Williams, M., Kim, B., McCreary, M., … & Wells, K. (2017). How do communities use a participatory public health approach to build resilience? the los angeles county community disaster resilience project. International Journal of Environmental Research and Public Health, 14(10), 1267. https://doi.org/10.3390/ijerph14101267

Chanthasri, W., Puangkeaw, N., Kunworarath, N., Jaisamut, P., Limsuwan, S., Maneenoon, K., … & Chusri, S. (2018). Antioxidant capacities and total phenolic contents of 20 polyherbal remedies used as tonics by folk healers in phatthalung and songkhla provinces, thailand. BMC Complementary and Alternative Medicine, 18(1). https://doi.org/10.1186/s12906-018-2131-y

Chebii, W., Muthee, J., & Kiemo, K. (2020). The governance of traditional medicine and herbal remedies in the selected local markets of kenya.. https://doi.org/10.21203/rs.2.21763/v1

Clithero-Eridon, A., Ross, S., Middleton, L., Reeve, C., & Neusy, A. (2017). Improving community health using an outcome-oriented cqi approach to community-engaged health professions education. Frontiers in Public Health, 5. https://doi.org/10.3389/fpubh.2017.00026

Cooke, H., Campbell, T., Anagnostopoulos, D., & Arnold, C. (2024). Environmental service learning as university-community partnership: using actor-network theory to examine a new model of engagement. Sage Open, 14(3). https://doi.org/10.1177/21582440241262830

Cunningham, C., Hutchings, T., Henderson, J., Rimas, H., & Chen, Y. (2016). Modeling the hospital safety partnership preferences of patients and their families: a discrete choice conjoint experiment. Patient Preference and Adherence, Volume 10, 1359-1372. https://doi.org/10.2147/ppa.s105605

David-Chavez, D., Gavin, M., Ortiz, N., Valdez, S., & Carroll, S. (2024). A values-centered relational science model: supporting indigenous rights and reconciliation in research. Ecology and Society, 29(2). https://doi.org/10.5751/es-14768-290211

Dewi, L., Widiana, I., & Jayanta, I. (2024). The project-based learning assessment guide (project-based learning) is oriented towards phenomenon-based learning. Journal of Education Research and Evaluation, 8(2), 362-372. https://doi.org/10.23887/jere.v8i2.74594

Drame, I., Gibson, C., Nonyel, N., Addo-Atuah, J., Butler, L., Riley, A., … & Borja‐Hart, N. (2022). Strategies for incorporating health disparities and cultural competency training into the pharmacy curriculum and co-curriculum. American Journal of Pharmaceutical Education, 86(3), 8631. https://doi.org/10.5688/ajpe8631

El-Said, K., Ali, F., & Mohamed, A. (2023). Biochemical and molecular mechanisms of annona sp. fruits extract in ehrlich ascites carcinoma-bearing mice. Journal of Medical and Life Science, 0(0), 142-154. https://doi.org/10.21608/jmals.2023.307798

Fonmboh, D., Abah, E., Fokunang, T., Hervé, B., Teke, G., Rose, N., … & Ntungwen, F. (2020). An overview of methods of extraction, isolation and characterization of natural medicinal plant products in improved traditional medicine research. Asian Journal of Research in Medical and Pharmaceutical Sciences, 31-57. https://doi.org/10.9734/ajrimps/2020/v9i230152

Fredriksson, M. (2021). India’s traditional knowledge digital library and the politics of patent classifications. Law and Critique, 34(1), 1-19. https://doi.org/10.1007/s10978-021-09299-7

Frezza, C. (2025). Unveiling the chemical profile of teucrium chamaedrys subsp. gracile (batt.) rech.f. dried aerial parts from algeria. Chemistry & Biodiversity. https://doi.org/10.1002/cbdv.202500236

Gavamukulya, Y., Maina, E., Meroka, A., Madivoli, E., Shemy, H., Magoma, G., … & Wamunyokoli, F. (2019). Liquid chromatography single quadrupole mass spectrometry (lc/sq ms) analysis reveals presence of novel antineoplastic metabolites in ethanolic extracts of fruits and leaves of annona muricata. Pharmacognosy Journal, 11(4), 660-668. https://doi.org/10.5530/pj.2019.11.104

Grundmann, O., Lobine, D., & Olopade, J. (2023). Editorial: education in ethnopharmacology 2022. Frontiers in Pharmacology, 14. https://doi.org/10.3389/fphar.2023.1154280

Halfter, K. and Mayer, B. (2017). Bringing 3d tumor models to the clinic – predictive value for personalized medicine. Biotechnology Journal, 12(2). https://doi.org/10.1002/biot.201600295

Hanif, S., Wijaya, A., & Winarno, N. (2019). Enhancing students’ creativity through stem project-based learning. Journal of Science Learning, 2(2), 50. https://doi.org/10.17509/jsl.v2i2.13271

Hausman-Cohen, S., Asamoah, N., Yee, C., Braun, I., Shick, M., Abdallah, A., … & Lipman, T. (2020). Community organizations’ perspectives on the impact of a nursing student-led academic-community partnership program. Journal of Nursing Education and Practice, 10(8), 9. https://doi.org/10.5430/jnep.v10n8p9

Humphries, D., Bastida, C., & Walker, M. (2021). Lessons from a community driven experiential public health course. Pedagogy in Health Promotion, 8(3), 231-237. https://doi.org/10.1177/23733799211056311

Huria, T., Palmer, S., Beckert, L., Lacey, C., & Pitama, S. (2017). Indigenous health: designing a clinical orientation program valued by learners. BMC Medical Education, 17(1). https://doi.org/10.1186/s12909-017-1019-8

Idris, K., Yusof, N., Rahman, T., Adnan, L., & Aziz, A. (2020). Analysis of antimicrobial compound in ziziphus mauritiana extract using attenuated total reflection-fourier transform infrared (atr-ftir). Malaysian Journal of Science Health & Technology, 7. https://doi.org/10.33102/mjosht.v7io.104

Jayanti, E. (2022). Etnobotani tumbuhan berkhasiat obat pada masyarakat karang bayan kabupaten lombok barat. Bioscientist Jurnal Ilmiah Biologi, 10(1), 409. https://doi.org/10.33394/bioscientist.v10i1.5272

Kashino, I., Serafini, M., Ishihara, J., Mizoue, T., Sunami, A., Maruyama, K., … & Tsugane, S. (2018). The validity and reproducibility of dietary non-enzymatic antioxidant capacity estimated by self-administered food frequency questionnaires. Journal of Epidemiology, 28(10), 428-436. https://doi.org/10.2188/jea.je20170063

Kegler, M., Blumenthal, D., Akintobi, T., Rodgers, K., Erwin, K., Thompson, W., … & Hopkins, E. (2016). Lessons learned from three models that use small grants for building academic-community partnerships for research. Journal of Health Care for the Poor and Underserved, 27(2), 527-548. https://doi.org/10.1353/hpu.2016.0076

Klein‐Júnior, L., Souza, M., Viaene, J., Bresolin, T., Gasper, A., Henriques, A., … & Heyden, Y. (2021). Quality control of herbal medicines: from traditional techniques to state-of-the-art approaches. Planta Medica, 87(12/13), 964-988. https://doi.org/10.1055/a-1529-8339

Koshevenko, A., Degrave, T., Burenkov, P., Belanov, K., & Kosenko, V. (2024). Roles of individual institutions in achieving pharmaceutical sovereignty as exemplified by the medical technology transfer centre of the scientific centre for expert evaluation of medicinal products. Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo pr, 14(5), 505-512. https://doi.org/10.30895/1991-2919-2024-14-5-505-512

Linn, M., Gerard, L., Matuk, C., & McElhaney, K. (2016). Science education. Review of Research in Education, 40(1), 529-587. https://doi.org/10.3102/0091732x16680788

Madhavan, H. (2017). Below the radar innovations and emerging property right approaches in tibetan medicine. The Journal of World Intellectual Property, 20(5-6), 239-257. https://doi.org/10.1111/jwip.12084

Manton, D., Williams, M., & Hayen, A. (2023). The bunya project: protocol for a mixed-methods approach to developing a culturally informed curriculum. Jmir Research Protocols, 12, e39864. https://doi.org/10.2196/39864

Martins, D., Rodrigues, E., Casu, L., Benítez, G., & Leonti, M. (2019). The historical development of pharmacopoeias and the inclusion of exotic herbal drugs with a focus on europe and brazil. Journal of Ethnopharmacology, 240, 111891. https://doi.org/10.1016/j.jep.2019.111891

McCarragher, S., Acuff, C., Cowden, C., & Beasley, D. (2024). A bibliometric analysis of urban greenway literature: implications for interdisciplinary research on urban systems. Discov Cities, 1(1). https://doi.org/10.1007/s44327-024-00027-1

Melo, P. and Alves, O. (2019). Community empowerment and community partnerships in nursing decision-making. Healthcare, 7(2), 76. https://doi.org/10.3390/healthcare7020076

Mikesell, L., Bromley, E., & Khodyakov, D. (2013). Ethical community-engaged research: a literature review. American Journal of Public Health, 103(12), e7-e14. https://doi.org/10.2105/ajph.2013.301605

Moghadamtousi, S., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H., & Kadir, H. (2015). Annona muricata (annonaceae): a review of its traditional uses, isolated acetogenins and biological activities. International Journal of Molecular Sciences, 16(7), 15625-15658. https://doi.org/10.3390/ijms160715625

Morais, C., Moreira, L., Baptista, M., & Martins, I. (2021). Digital tools entering the scene in stem activities for physics teaching., 124-137. https://doi.org/10.1007/978-3-030-73988-1_9

Mulumba, M., Oga, J., Koomson, N., Kara, T., Forman, L., & Cynthia, A. (2024). Decolonizing global health: africa’s pursuit of pharmaceutical sovereignty.. https://doi.org/10.21203/rs.3.rs-4271227/v1

Nicholson, V., Bratu, A., McClean, A., Jawanda, S., Aran, N., Hillstrom, K., … & Team, B. (2021). Indigenizing our research. International Journal for Population Data Science, 6(1). https://doi.org/10.23889/ijpds.v6i1.1386

Noerhadi, C. (2020). Normative structure of indonesian pharmacy trade secret law. Linguistics and Culture Review, 5(S4), 2413-2426. https://doi.org/10.21744/lingcure.v5ns4.2008

Osho, I. and Durojaye, C. (2023). In vitro and in vivo antitrypanosomal activities of annona muricata leaf extracts in trypanosoma brucei brucei experimentally infected albino rats. International Journal of Tropical Disease & Health, 44(8), 23-32. https://doi.org/10.9734/ijtdh/2023/v44i81424

Ozkan, M., Aliyazıcıoğlu, R., Demir, S., Mısır, S., Turan, İ., Yıldırmış, S., … & Aliyazıcıoğlu, Y. (2016). Phenolic characterisation and antioxidant activity of primula vulgaris and its antigenotoxic effect on fibroblast cells. Jundishapur Journal of Natural Pharmaceutical Products, 12(1). https://doi.org/10.5812/jjnpp.40073

Pedrami, F., Asenso, P., & Devi, S. (2016). Using text analytics of ajpe article titles to reveal trends in pharmacy education over the past two decades. American Journal of Pharmaceutical Education, 80(6), 104. https://doi.org/10.5688/ajpe806104

Perng, W. and Aslibekyan, S. (2020). Find the needle in the haystack, then find it again: replication and validation in the ‘omics era. Metabolites, 10(7), 286. https://doi.org/10.3390/metabo10070286

Pino‐García, R., García‐Lomillo, J., Rivero-Pérez, M., José, M., & Múñiz, P. (2015). Adaptation and validation of quick, easy, new, cheap, and reproducible (quencher) antioxidant capacity assays in model products obtained from residual wine pomace. Journal of Agricultural and Food Chemistry, 63(31), 6922-6931. https://doi.org/10.1021/acs.jafc.5b01644

Pirintsos, S., Panagiotopoulos, A., Bariotakis, M., Daskalakis, V., Lionis, C., Sourvinos, G., … & Castanas, E. (2022). From traditional ethnopharmacology to modern natural drug discovery: a methodology discussion and specific examples. Molecules, 27(13), 4060. https://doi.org/10.3390/molecules27134060

Pitama, S., Palmer, S., Huria, T., Lacey, C., & Wilkinson, T. (2018). Implementation and impact of indigenous health curricula: a systematic review. Medical Education, 52(9), 898-909. https://doi.org/10.1111/medu.13613

Rana, P. and Deva, P. (2023). History of the profession of pharmacy in india.. https://doi.org/10.52458/9788196830045.2023.eb.ch-02

Reams, R., Odedina, F., Carpten, J., Redda, K., Stern, M., Krieger, J., … & Wilkie, D. (2023). Florida-california cancer research, education and engagement (care2) health equity center: structure, innovations, and initial outcomes. Cancer Control, 30. https://doi.org/10.1177/10732748231197878

Redmond, C., Farrell, R., Cunningham, C., Dineen, A., Foley, S., O’Donnell, D., … & O’Neill, E. (2023). Development of the evibec learning outcomes framework to support the delivery of evidence-based practice curricula in health care professional programmes: a codesign approach.. https://doi.org/10.21203/rs.3.rs-3310504/v1

Rigat, M., Vallès, J., D’Ambrosio, U., Gras, A., Iglésias, J., & Garnatje, T. (2015). Plants with topical uses in the ripollès district (pyrenees, catalonia, iberian peninsula): ethnobotanical survey and pharmacological validation in the literature. Journal of Ethnopharmacology, 164, 162-179. https://doi.org/10.1016/j.jep.2015.01.055

Robinson, A., Takyi, C., Chan, H., & Lau, W. (2023). Embedding cultural competency and cultural humility in undergraduate pharmacist initial education and training: a qualitative exploration of pharmacy student perspectives. International Journal of Clinical Pharmacy, 46(1), 166-176. https://doi.org/10.1007/s11096-023-01665-y

Rosalina, L., Mahendika, D., Asyura, M., Aziz, S., & Djafar, T. (2023). Utilization of ziziphus mauritiana leaves for lowering cholesterol level. Jurnal Penelitian Pendidikan IPA, 9(9), 737-741. https://doi.org/10.29303/jppipa.v9i9.4268

Rotz, M., Dueñas, G., Zanoni, A., & Grover, A. (2016). Designing and evaluating an interprofessional experiential course series involving medical and pharmacy students. American Journal of Pharmaceutical Education, 80(5), 85. https://doi.org/10.5688/ajpe80585

Schröders, J., Wall, S., Kusnanto, H., & Ng, N. (2015). Millennium development goal four and child health inequities in indonesia: a systematic review of the literature. Plos One, 10(5), e0123629. https://doi.org/10.1371/journal.pone.0123629

Sheba, L. and Venkatraman, A. (2021). Physicochemical characterization, phytochemical and hptlc fingerprinting studies on fruit of couroupita guianensis. Chiang Mai University Journal of Natural Sciences, 20(4). https://doi.org/10.12982/cmujns.2021.078

Smith, S. and Blumenthal, D. (2012). Community health workers support community-based participatory research ethics: lessons learned along the research-to-practice-to-community continuum. Journal of Health Care for the Poor and Underserved, 23(4a), 77-87. https://doi.org/10.1353/hpu.2012.0156

Song, Y., Chung, E., Lee, Y., Yoon, J., & Kim, H. (2023). Objective structured clinical examination as a competency assessment tool of students’ readiness for advanced pharmacy practice experiences in south korea: a pilot study. BMC Medical Education, 23(1). https://doi.org/10.1186/s12909-023-04226-z

Sugara, T., Fitriana, Y., Koswara, I., Fahrurrozi, F., Chasanah, E., Adam, M., … & Furqani, N. (2025). Secondary metabolite profile and free-radical scavenging activity of ethyl acetate extract of bidara fruit and leaves (ziziphus mauritiana). Iop Conference Series Earth and Environmental Science, 1441(1), 012013. https://doi.org/10.1088/1755-1315/1441/1/012013

Supatmiwati, D., Kartarina, K., Suktiningsih, W., Hastuti, H., & Sriwinarti, N. (2025). Digitization of sasak traditional medicine: an effort to preserve local language on medicine plants. Humanus, 24(1), 47. https://doi.org/10.24036/humanus.v24i1.125818

Tan, E., Low, L., Atanasov, A., & Goh, B. (2025). Bridging traditions and technology: the role of ethnopharmacology in shaping next‐generation multidisciplinary researchers. Pharmacology Research & Perspectives, 13(1). https://doi.org/10.1002/prp2.70074

Thippeswamy, B., Chinnadhurai, M., Kandasamy, G., Vasudevan, R., Sam, G., & Karunakarannair, A. (2023). Ziziphus mauritiana leaves normalize hormonal profile and total cholesterol in polycystic ovarian syndrome rats. Plants, 12(14), 2599. https://doi.org/10.3390/plants12142599

Usmeldi, U. and Amini, R. (2022). Creative project-based learning model to increase creativity of vocational high school students. International Journal of Evaluation and Research in Education (Ijere), 11(4), 2155. https://doi.org/10.11591/ijere.v11i4.21214

Waldner, B., Machalett, R., Schönbichler, S., Dittmer, M., Rubner, M., & Intelmann, D. (2020). Fast evaluation of herbal substance class composition by relative mass defect plots. Analytical Chemistry, 92(19), 12909-12916. https://doi.org/10.1021/acs.analchem.0c01447

Yang, Y., Han, K., Liu, Z., Xie, S., Xu, J., He, Y., … & Yang, X. (2024). Ultrasonic‐assisted biphasic aqueous extraction of polyphenols from vaccinium dunalianum leaves: optimization, antioxidant, and tyrosinase inhibition activities. Chemistry & Biodiversity, 21(11). https://doi.org/10.1002/cbdv.202400955

Zhou, X., Seto, S., Chang, D., Kiat, H., Razmovski‐Naumovski, V., Chan, K., … & Bensoussan, A. (2016). Synergistic effects of chinese herbal medicine: a comprehensive review of methodology and current research. Frontiers in Pharmacology, 7. https://doi.org/10.3389/fphar.2016.00201

Zvonkovic, A., Standifer, A., Dumlao, R., & Gavazzi, S. (2024). Addressing campus–community relationships using the three corners marriage model. Journal of Family Theory & Review, 17(1), 73-91. https://doi.org/10.1111/jftr.12596

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2025-07-30

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Bayani, F., Rokhmat, J., Hakim, A., & Sukarso, A. (2025). Integrating Indigenous Knowledge through Contextual Project-Based Learning: Student–Healer Collaboration and Phytochemical Investigation of Traditional Ethnomedicine in Lombok, Indonesia. Prisma Sains : Jurnal Pengkajian Ilmu Dan Pembelajaran Matematika Dan IPA IKIP Mataram, 13(3), 895–915. https://doi.org/10.33394/j-ps.v13i3.17348

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