In Vitro Evaluation of the Anti-Diabetic Potential of Oxovanadium(IV) Complex with Terpyridine Ligand

Authors

  • Fakhrotun Nisa Chemistry Department, Faculty of Mathematics and Natural Science, Universitas Pamulang, Jl. Suryakencana No. 1, Tangerang Selatan, Indonesia
  • Djulia Onggo Chemistry Department, Faculty of Mathematics and Natural Science, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung, Indonesia

DOI:

https://doi.org/10.33394/hjkk.v14i2.20322

Keywords:

Complex, Oxovanadium(iv), Terpyridine, In Vitro, Antidiabetic

Abstract

An oxovanadium(IV) complex with 2,2′:6′,2″-terpyridine ligand, [VO(terpy)]SO₄, was synthesized and characterized to evaluate its anti-diabetic potential. The complex was synthesized via a direct reaction between VOSO₄ as the metal source and terpyridine ligand in solution and confirmed through conductometric and mass spectrometric analyses. Conductivity measurements indicated that the complex behaves as a 2:2 electrolyte in aqueous solution, dissociating into [VO(terpy)]²⁺ and SO₄²⁻ ions. Mass spectrometry revealed a peak at m/z 150.0098 corresponding to the cationic species. The anti-diabetic activity was evaluated through in vivo studies using alloxan-induced diabetic rats, demonstrating a significant reduction in fasting blood glucose levels. These findings suggest that the oxovanadium(IV)–terpyridine complex is a candidate for further development as an anti-diabetic agent.

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Published

2026-04-30

How to Cite

Nisa, F., & Onggo, D. (2026). In Vitro Evaluation of the Anti-Diabetic Potential of Oxovanadium(IV) Complex with Terpyridine Ligand. Hydrogen: Jurnal Kependidikan Kimia, 14(2). https://doi.org/10.33394/hjkk.v14i2.20322

Issue

Vol. 14 No. 2 (2026): April 2026

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Articles

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Copyright (c) 2026 Fakhrotun Nisa, Djulia Onggo

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